Katholieke Universiteit Leuven (KU Leuven)

Study by Seyedehsamaneh Ekhteraeitousi: Adult cardiomyocytes are sensitive to oxygen changes, leading to cell death and heart issues. In contrast, fetal cardiomyocytes resist low oxygen, using glycolysis. After birth, they switch to glycolysis and fatty acid oxidation but lose hypoxia tolerance regulated by HIF. The research seeks to understand these changes and find genes to prevent cardiomyocyte necrosis and maintain energy production, advancing heart disease treatment and personalized medicine.