Université Catholique de Louvain

Project of Françoise Van Bambeke supported by the Fund A & J Forton and muco.be : 'Lung infection in CF are difficult to treat because of resistance and biofilm-related tolerance to antibiotics. We will evaluate in biofilm models the potential synergy between antibiotics and mucolytic agents and phages, which could contribute to disturb the biofilm matrix and kill bacteria respectively. We will study the mechanism of these synergies. We will explore the co-evolution of bacteria and phages in biofilms. We will examine the transcriptome and metabolome of biofilms'