KU Leuven
Fertility deficiency in female cystic fibrosis patients: deciphering the role of the endometrium as prime player into pregnancy
2023
Leuven
Project of Hugo Vankelecom supported by the Fund A & J Forton and the Belgian CF Association muco .be : 'Many female cystic fibrosis (CF) patients suffer from sub- to infertility. Involvement of the womb’s endometrium, prime tissue for reproduction, is understudied due to lack of proper research models. We apply tissue-mimicking organoids from fertility-deficient CF endometrium to decipher molecular/functional aberrations as compared to fertile endometrium. This comparison will guide us to endometrial causes underlying CF fertility deficiency, as well as to candidate fertility-improving treatments'