Université Catholique de Louvain
Transcriptome study of individual cells isolated from synovial biopsies: can it help in the therapeutic management of early rheumatoid arthritis ?
Supported project of Patrick Durez : Early diagnosis and therapeutic management of Rheumatoid arthritis (RA) are crucial. Early RA is treated with methotrexate (MTX) and after 3 months, approximately 45% of patients are in remission or low disease activity. There is no biomarker that can predict the level of response to MTX. The objective is to identify a transcriptomic signature associated with clinical response to MTX. We will analyze by scRNAseq synovial cells from 20 patients at baseline and at 16 weeks for non-responders.
Have also benefited from support
KU Leuven (RA Clinical Research Group, Skeletal Biology and Engineering Research Centre, Department of Development and Regeneration, KU Leuven)
What is the optimal tapering strategy for rituximab in patients with Rheumatoid Arthritis: comparison of interval prolongation with disease activity guided dose reduction
Supported project of Patrick Verschueren : Rituximab is an effective drug, but it is expensive and might be accompanied by an increased infection risk. Therefore, lowering the do…
UZ Leuven/ KU Leuven
Clinical field tests as predictors of cardiorespiratory fitness and cardiometabolic risk in Psoriatic Arthritis.
Supported project of Barbara Neerinckx : This project will study the potential of low cost, objective and highly generalisable clinical field tests, six minute walk and hand grip…