Hôpital Universitaire des Enfants Reine Fabiola (HUDERF)

Project lead by Georges Casimir : 'The aim of this work is to evaluate the role of the X chromosome in the sex differences in inflammatory diseases in children. To discriminate more precisely the X chromosome role relatively to the sex steroids in the sex-specific inflammatory response, we will evaluate some innate immune functions related to X-linked The aim of this work is to evaluate the role of the X chromosome in the sex differences in inflammatory diseases in children. To discriminate more precisely the X chromosome role relatively to the sex steroids in the sex-specific inflammatory response, we will evaluate some innate immune functions related to X-linked genes, in whole blood from prepubertal children of both sexes, suffering from acute inflammatory processes such as E.Coli pyelonephritis, pneumonia with pleural effusion or sepsis'