Universiteit Antwerpen
Identification of cell-specific disease genes for bicuspid aortic valve-related aortopathy by transcriptome-wide spatial profiling of a representative Smad6 mutant mouse model
2024
In this project, I aim to improve the molecular basis of bicuspid aortic valve-related aortopathy by identifying early cell-specific disease genes in a representative Smad6 mutant mouse model using transcriptome-wide spatial profiling on embryonic tissue. With SMAD6 being the most common mutated gene, I will tackle our current gap in knowledge on the pathogenic basis underlying this disease in order to advance patient management.