Gent University
3D-RET: unlocking 3D genome architecture in human retina, a novel target for intervention
2022
Gent
Inherited retinal diseases (IRD) cause blindness in two million people worldwide. Multi-omics in human retina contribute to non-coding variant interpretation in IRD. Yet, the 3D genome in human retina is unknown and we hypothesize that a specific 3D architecture exists. We will investigate 3D genome structure in adult human retina and determine effects of structural variants (SVs) on the 3D genome in patient’s cells. This will unlock the 3D genome in retina, a novel target for intervention.